000			03292nam a22005415i 4500
001			978-3-319-60192-2
003			DE-He213
005			20190313085144.0
007			cr nn 008mamaa
008			170914s2017 gw | s |||| 0|eng d
020			_a9783319601922 _9978-3-319-60192-2
024	7		_a10.1007/978-3-319-60192-2 _2doi
050		4	_aRB155-155.8
050		4	_aQH431
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
245	1	0	_aGenome Editing in Neurosciences _h[electronic resource] / _cedited by Rudolf Jaenisch, Feng Zhang, Fred Gage.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2017.
300			_aXI, 123 p. 16 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aResearch and Perspectives in Neurosciences, _x0945-6082
505	0		_aIntroduction -- In vitro modeling of complex neurological diseases -- Aquatic model organisms in neurosciences : the genome editing revolution -- Genome-wide genetic screening in the mammalian CNS -- CRISPR/Cas9-mediated Knockin and Knockout in Zebrafish -- Dissecting the role of synaptic proteins with CRISPR -- Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer -- Neuroscience research using non-human primate models and genome editing -- Multiscale genome engineering: Genome-wide screens and targeted approaches -- Using Genome Engineering to Understand Huntington’s Disease -- Therapeutic gene editing in muscles and muscle stem cells.
506	0		_aOpen Access
520			_aThis book is open access under a CC BY 4.0 license. Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aNeurosciences.
650		0	_aBiomedical engineering.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Genetics.
650	2	4	_aNeurosciences.
650	2	4	_aBiomedical Engineering/Biotechnology.
700	1		_aJaenisch, Rudolf. _eeditor.
700	1		_aZhang, Feng. _eeditor.
700	1		_aGage, Fred. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783319601915
830		0	_aResearch and Perspectives in Neurosciences, _x0945-6082
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-319-60192-2
912			_aZDB-2-SBL
999			_c48515 _d48515