000 | 02612nam a22004695i 4500 | ||
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001 | 978-3-319-65639-7 | ||
003 | DE-He213 | ||
005 | 20190313085146.0 | ||
007 | cr nn 008mamaa | ||
008 | 171103s2018 gw | s |||| 0|eng d | ||
020 |
_a9783319656397 _9978-3-319-65639-7 |
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024 | 7 |
_a10.1007/978-3-319-65639-7 _2doi |
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050 | 4 | _aR-RZ | |
072 | 7 |
_aMBGR _2bicssc |
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072 | 7 |
_aMED000000 _2bisacsh |
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082 | 0 | 4 |
_a610 _223 |
245 | 1 | 0 |
_aSelf-Assembled Molecules – New Kind of Protein Ligands _h[electronic resource] : _bSupramolecular Ligands / _cedited by Irena Roterman, Leszek Konieczny. |
264 | 1 |
_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2018. |
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300 |
_aXII, 136 p. 98 illus., 44 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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506 | 0 | _aOpen Access | |
520 | _aThis book is an open access under a CC BY license. The subject of this book relates to protein ligands with particular structural and complexation properties. They are composed of self-assembled molecules, capable of penetrating as a unit into proteins outside the binding site. The ribbon-like supramolecular system only permits the penetration of self-assembled molecules into the protein-body and formation of stable complexes. Supramolecular Congo red and similar compounds fit these requirements. Destabilized protein fragments enable the penetration of such ligands, with susceptibility to supramolecular ligand binding often associated with protein function. As a result, complexation modifies their functional effects. The activity of enzymes is inhibited by arresting them in the complexed state, but “naturally irreversible” complexation as in the case of immune complexation, is enhanced instead. This property offers many attractive possibilities of using supramolecular ligands as described in this book. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aProteins. | |
650 | 0 |
_aBiology _xTechnique. |
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650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aBiomedicine general. |
650 | 2 | 4 | _aProtein Science. |
650 | 2 | 4 | _aProtein-Ligand Interactions. |
650 | 2 | 4 | _aBiological Techniques. |
700 | 1 |
_aRoterman, Irena. _eeditor. |
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700 | 1 |
_aKonieczny, Leszek. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783319656380 |
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-319-65639-7 |
912 | _aZDB-2-SBL | ||
999 |
_c48542 _d48542 |