000 02612nam a22004695i 4500
001 978-3-319-65639-7
003 DE-He213
005 20190313085146.0
007 cr nn 008mamaa
008 171103s2018 gw | s |||| 0|eng d
020 _a9783319656397
_9978-3-319-65639-7
024 7 _a10.1007/978-3-319-65639-7
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
245 1 0 _aSelf-Assembled Molecules – New Kind of Protein Ligands
_h[electronic resource] :
_bSupramolecular Ligands /
_cedited by Irena Roterman, Leszek Konieczny.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2018.
300 _aXII, 136 p. 98 illus., 44 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
506 0 _aOpen Access
520 _aThis book is an open access under a CC BY license.  The subject of this book relates to protein ligands with particular structural and complexation properties. They are composed of self-assembled molecules, capable of penetrating as a unit into proteins outside the binding site. The ribbon-like supramolecular system only permits the penetration of self-assembled molecules into the protein-body and formation of stable complexes. Supramolecular Congo red and similar compounds fit these requirements. Destabilized protein fragments enable the penetration of such ligands, with susceptibility to supramolecular ligand binding often associated with protein function. As a result, complexation modifies their functional effects. The activity of enzymes is inhibited by arresting them in the complexed state, but “naturally irreversible” complexation as in the case of immune complexation, is enhanced instead. This property offers many attractive possibilities of using supramolecular ligands as described in this book.
650 0 _aMedicine.
650 0 _aProteins.
650 0 _aBiology
_xTechnique.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aProtein Science.
650 2 4 _aProtein-Ligand Interactions.
650 2 4 _aBiological Techniques.
700 1 _aRoterman, Irena.
_eeditor.
700 1 _aKonieczny, Leszek.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319656380
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-65639-7
912 _aZDB-2-SBL
999 _c48542
_d48542